Tilting would be significant if the camera uses base tilt. Base tilt moves the lens and the camera must be re-focussed.
If you like to focus first, later tilting the lens needs re-focusing, yes.
The other way, described by Mr. Schoen for his Linhof papers or by Mr. Merklinger using the full Scheimpflug rules ( "hinge rule"), takes the lens in place first.
But how do you do both tilt and
Center focus?
To me the focusing method depends on subject and distances, the operation depends on the camera.
My long gone Shen Hao HZX 45 II has absolutely been my fastest camera.
It was so easy to tilt the lens in each directionand simultaneous doing the bellows movements.
Saying this I have found nearly the same with old Plaubel rail cameras.
Only the groundglass and fresh eyes have been the controlling elements.
My Reisekameras and the Mentor Studio need more patience and doing things step by step.
Best way outdoor to me then is setting the tilt degree first.
You have to use some guideline. Otherwise do you pick F/4 or F/22?
The guidline could be " if avoiding stopping dow too far is needed, Scheimpflug comes along".
This rule isn't only for wide sharpness in the field but good for more open apertures, too.
The choice of using f4 or f22 to me is an artistic question.
I can't imagine stopping down my SF lenses.
Vice versa for overall sharp landscapes.
David, speaking with now retired master professionals they never heard much or cared less about COC or resolution of film or MTF curves.
I have heard statements like "I have had to photograph, I haven't the time for technicals discussions.
Great

They made huge enlargements some meters long, enlarged in old cinemas.
Of course they knew about the lack of sharpness but who cares if the print is hanging on a skyscraper.
Obvisiously if we need the best results we have to go more to the depth using math for tilting and focusing, CoC formulas and slow film with high resolution.
All depends on the size of the enlargement and of the viewer's distance.
How difficult to handle all steps from film choice and lens choice over film flatness to focusing right, exposure and development and finally managing enlargement influence will be shown from large enlargements.
This could start with a print of 20x24".