That's what I do with the exception of setting the black and white points (levels) on the histogram. Everything else is off. Settings I use are 2400dpi resolution and 16 bit grayscale or 48 bit color.One other thing that can exaggerate grain in scanning B+W negatives is the dust and scratch removal function. The scanner sees grain as dust and attempts to remove it, sometimes with very odd results. There may be settings that circumvent this. I believe the general advice on scanning is to let the scanner's software do as little as possible and reserve all corrections for later.
www.google.com
You have the option to dry mount the negs on the Epson fluid mount, you just need a piece of anti newton glass to sit on top of the negative, works extremely well for 4x5 negs, keeps them dead flat and the height seems to give optimum sharpness, I only wet mount if there badly scratched or full of dust particles that cant be mechanically removed, wet mounting helps in that scenario
www.digitalblackandwhite.co.uk
I have tried that way with high and low res lens but the results were worse than the wet holder